Transporters of nucleotide sugars, nucleotide sulfate and ATP in the Golgi apparatus

Proteins and glycolipids are glycosylated, sulfated and phosphorylated in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must first be translocated from the cytosol into the Golgi lumen by specific transporters (antiporters). These are hydrophobic, transmembrane-spann...

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Bibliographic Details
Published in:Trends in Biochemical Sciences 1997-06, Vol.22 (6), p.203-207
Main Authors: Abeijon, Claudia, Mandon, Elisabet C., Hirschberg, Carlos B.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Antiporters - chemistry
Antiporters - metabolism
Biological Transport
Carbohydrate Metabolism
Endoplasmic Reticulum - metabolism
Glycosylation
Golgi Apparatus - metabolism
Mutation
Nucleotides - metabolism
Phosphorylation
Sulfates - metabolism
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Summary:Proteins and glycolipids are glycosylated, sulfated and phosphorylated in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must first be translocated from the cytosol into the Golgi lumen by specific transporters (antiporters). These are hydrophobic, transmembrane-spanning proteins that appear to regulate post-translational modifications in the Golgi lumen.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(97)01053-0