Studies on a novel antitumor antibiotic, phenazinomycin: taxonomy, fermentation, isolation, and physicochemical and biological characteristics

A new antibiotic, phenazinomycin (C27H32N2O, MW 400), was isolated from the cultural mycelium of Streptomyces sp. WK-2057. This antibiotic possesses antibacterial activities against Gram-positive bacteria in vitro, direct cytotoxic activities against HeLa S3, P388 and P388 doxorubicin-resistant cell...

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Bibliographic Details
Published in:Journal of antibiotics 1989, Vol.42 (7), p.1037-1042
Main Authors: Omura, S, Eda, S, Funayama, S, Komiyama, K, Takahashi, Y, Woodruff, H B
Format: Article
Language:English
Subjects:
Animals
antibacterial agents
Antibiotics, Antineoplastic - analysis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, Antineoplastic - therapeutic use
antitumor antibiotics
Bacteria - drug effects
Fermentation
gram-positive bacteria
HeLa Cells
Leukemia P388 - drug therapy
Leukemia, Experimental - drug therapy
Magnetic Resonance Spectroscopy
Male
Mass Spectrometry
Mice
Mice, Inbred ICR
Microscopy, Electron
Molecular Structure
Phenazines - analysis
Phenazines - isolation & purification
Phenazines - pharmacology
Phenazines - therapeutic use
Sarcoma 180 - drug therapy
Soil Microbiology
Spectrophotometry, Infrared
Streptomyces
Streptomyces - classification
Streptomyces - metabolism
Streptomyces - ultrastructure
Tumor Cells, Cultured
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Description
Summary:A new antibiotic, phenazinomycin (C27H32N2O, MW 400), was isolated from the cultural mycelium of Streptomyces sp. WK-2057. This antibiotic possesses antibacterial activities against Gram-positive bacteria in vitro, direct cytotoxic activities against HeLa S3, P388 and P388 doxorubicin-resistant cells in vitro and antitumor activities against experimental murine tumors in vivo.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.1037