Cyclothialidine Analogs, Novel DNA Gyrase Inhibitors

DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analog...

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Bibliographic Details
Published in:Journal of antibiotics 1997/05/25, Vol.50(5), pp.402-411
Main Authors: YAMAJI, KAYOKO, MASUBUCHI, MIYAKO, KAWAHARA, FUMIKO, NAKAMURA, YUMIKO, NISHIO, AYA, MATSUKUMA, SHOKO, FUJIMORI, MIKAKO, NAKADA, NAOKI, WATANABE, JUNKO, KAMIYAMA, TSUTOMU
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Biological and medical sciences
Chromatography, High Pressure Liquid
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
Medical sciences
Microbiology
Molecular Structure
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Stereoisomerism
Streptomyces
Structure-Activity Relationship
Topoisomerase II Inhibitors
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Summary:DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates. Cyclothialidines B, D and E are novel and potent inhibitors of DNA gyrase.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.50.402