Overexpression of the epidermal growth factor receptor gene in a human carcinoma cell line, derived from a brain metastasis

Abnormally high expression of epidermal growth factor receptors (EGF-receptors) may contribute to the unregulated growth of some tumors. We here report the EGF-receptor numbers and the effects of epidermal growth factor (EGF) on two human cell lines. The glioblastoma cell line T-MG1 had 135,000 EGF-...

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Bibliographic Details
Published in:Journal of neuro-oncology 1989-05, Vol.7 (1), p.81-88
Main Authors: HELSETH, E, DALEN, A, UNSGAARD, G, VIK, R, HELSETH, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Neoplasms - metabolism
Brain Neoplasms - secondary
Carcinoma - metabolism
Carcinoma - secondary
Cell Division - drug effects
Epidermal Growth Factor - pharmacology
ErbB Receptors - drug effects
ErbB Receptors - genetics
ErbB Receptors - metabolism
Gene Expression Regulation
Humans
Medical sciences
Neoplasm Metastasis
Neurology
Time Factors
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - metabolism
Tumors of the nervous system. Phacomatoses
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Summary:Abnormally high expression of epidermal growth factor receptors (EGF-receptors) may contribute to the unregulated growth of some tumors. We here report the EGF-receptor numbers and the effects of epidermal growth factor (EGF) on two human cell lines. The glioblastoma cell line T-MG1 had 135,000 EGF-receptors per cell, was slightly growth stimulated by EGF and showed no obvious change in morphology after exposure to EGF. The carcinoma cell line T-CAR1, derived from a brain metastasis of a carcinoma of the adrenal cortex, had approximately 7 million EGF-receptors per cell. EGF had a significant antiproliferative effect on these cells and caused rounding and detachment of cells in adherent cultures. The cell lines may become useful in future studies concerning the role of the EGF-receptors in malignant growth.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00149382