Effect of Dengue Virus on Procoagulant and Fibrinolytic Activities of Monocytes

Some of the fibrinolytic and coagulation enzymes that monocytes produce are urokinase, a plasminogen activator (PA); a PA-specific inhibitor (PAI); and procoagulant activity (PCA), which has been characterized as tissue factor. Dengue infection in vivo is restricted to monocytes; however, it is unkn...

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Bibliographic Details
Published in:Reviews of infectious diseases 1989-05, Vol.11, p.S843-S846
Main Authors: Krishnamurti, Chitra, Alving, Barbara
Format: Article
Language:English
Subjects:
Antibodies
Arboviroses
Biological and medical sciences
Blood Coagulation
Blood Coagulation Factors - biosynthesis
Cells, Cultured
Dengue
Dengue and Kyasanur Forest Disease
Dengue fevers
Dengue hemorrhagic fever
Dengue virus
Dengue Virus - physiology
Endothelial cells
Fibrinolysis
Fibrinolytics
Glycoproteins - biosynthesis
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Monocytes
Monocytes - enzymology
Monocytes - metabolism
Monocytes - microbiology
Plasminogen activators
Plasminogen Activators - antagonists & inhibitors
Plasminogen Activators - biosynthesis
Plasminogen Inactivators
Tropical medicine
Tropical viral diseases
Urokinase-Type Plasminogen Activator - metabolism
Viral diseases
Viruses
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Summary:Some of the fibrinolytic and coagulation enzymes that monocytes produce are urokinase, a plasminogen activator (PA); a PA-specific inhibitor (PAI); and procoagulant activity (PCA), which has been characterized as tissue factor. Dengue infection in vivo is restricted to monocytes; however, it is unknown if dengue-infected monocytes undergo alterations in the production of PA, PAI, and PCA. This issue was addressed in studies in which monocytes were infected in vitro with dengue 2 virus in serum-free medium in the presence of enhancing antibody. No urokinase activity was detected in either control or infected cells or in their supernatants. Infection of monocytes with dengue 2 virus resulted in an almost threefold increase in PAI activity in cells and supernatants. No change in relation to the control was observed in PCA generated by the infected cells. These data indicate that dengue 2 infection enhances the production of PAI from monocytes without altering PA or PCA.
ISSN:0162-0886