A preliminary study of the analysis of Cannabis by supercritical fluid chromatography with atmospheric pressure chemical ionisation mass spectroscopic detection

A rapid method is described for the analysis of Cannabis products by supercritical fluid chromatography (SFC) coupled to atmospheric pressure chemical ionization-mass spectroscopic (APCI-MS) detection. The method had a shorter analysis time than GC-MS methods, without the need for derivatization pri...

Full description

Saved in:
Bibliographic Details
Published in:Science & justice 1997-04, Vol.37 (2), p.91-97
Main Authors: Bäckström, B., Cole, M.D., Carrott, M.J., Jones, D.C., Davidson, G., Coleman, K.
Format: Article
Language:English
Subjects:
Atmospheric pressure chemical ionization mass spectroscopy
Cannabinoids - analysis
Cannabis
Cannabis - chemistry
Chromatography, High Pressure Liquid
Chromatography, Liquid - methods
Dronabinol - analysis
Drug identification
Drugs of abuse
Forensic science
Gas Chromatography-Mass Spectrometry
Mass Spectrometry
Supercritical fluid chromatography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A rapid method is described for the analysis of Cannabis products by supercritical fluid chromatography (SFC) coupled to atmospheric pressure chemical ionization-mass spectroscopic (APCI-MS) detection. The method had a shorter analysis time than GC-MS methods, without the need for derivatization prior to analysis. It was also faster than HPLC methods, with better resolution and definitive identification. Linearity of detector response to cannabidiol, delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol and cannabinol was established, the detection limits for mass on column being 0.55 ng, 1.20 ng, 0.69 ng and 2.10 ng respectively. The technique offers a means by which Cannabis products can be definitively identified in a single chromatographic run. Application to casework samples is described.
ISSN:1355-0306
1876-4452
DOI:10.1016/S1355-0306(97)72153-1