The influence of hydroxyapatite and pyrophosphate on the formation product of calcium oxalate at different pHs

The nucleating effect of hydroxyapatite (HAP) and the inhibitory effect of pyrophosphate (PPi) on calcium oxalate crystallization have been studied at different pH's in solution metastabely supersaturated with respect to calcium oxalate but saturated with respect to HAP. Crystallization was mon...

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Bibliographic Details
Published in:Urological research 1989-05, Vol.17 (3), p.153-155
Main Authors: Baumann, J M, Ackermann, D, Affolter, B
Format: Article
Language:English
Subjects:
Calcium Oxalate
Crystallization
Diphosphates - pharmacology
Durapatite
Humans
Hydrogen-Ion Concentration
Hydroxyapatites - pharmacology
In Vitro Techniques
Urinary Calculi - etiology
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Summary:The nucleating effect of hydroxyapatite (HAP) and the inhibitory effect of pyrophosphate (PPi) on calcium oxalate crystallization have been studied at different pH's in solution metastabely supersaturated with respect to calcium oxalate but saturated with respect to HAP. Crystallization was monitored by a decrease of calcium in the supernatant and formation products were calculated. At a pH above 6.0 already minimal HAP concentrations proved to be a suitable substrate for heterogeneous nucleation and growth of calcium oxalate. PPi showed a pronounced inhibitory effect on spontaneous as well as on HAP induced crystallization of calcium oxalate, this effect being highly pH dependent. HAP was found to neutralize the inhibitory effect of PPi in a molar ratio of 10:1.
ISSN:0300-5623
1434-0879
DOI:10.1007/BF00256242