Cyclo (His-Pro) modulation of body temperature at hot ambient temperature in the desert rat (Mastomys natalensis)

Cyclo(His-Pro) (CHP) has been shown to facilitate cold-induced hypothermia in the desert rat Mastomys natalensis. In the present study, we examined the role of endogenous CHP in hyperthermia induced by hot ambient temperature (40 degrees C) in the above rodent species. The results of these studies s...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1997, Vol.18 (5), p.689-693
Main Authors: Shukla, R, Srimal, R C, Prasad, C
Format: Article
Language:English
Subjects:
Animals
Body Temperature Regulation - drug effects
Body Temperature Regulation - physiology
Brain Chemistry - drug effects
Fever - metabolism
Hot Temperature - adverse effects
Injections, Intraventricular
Muridae
Peptides, Cyclic - administration & dosage
Peptides, Cyclic - analysis
Piperazines - administration & dosage
Piperazines - analysis
Rats
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Summary:Cyclo(His-Pro) (CHP) has been shown to facilitate cold-induced hypothermia in the desert rat Mastomys natalensis. In the present study, we examined the role of endogenous CHP in hyperthermia induced by hot ambient temperature (40 degrees C) in the above rodent species. The results of these studies show that housing rodents at 40 degrees C resulted in a altered distribution of CHP in the brain, with a rise in hypothalamic content accompanied by an increase in rectal temperature. While administration of exogenous CHP decreased hyperthermia, immunoneutralization of endogenous CHP increased hyperthermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation.
ISSN:0196-9781
DOI:10.1016/S0196-9781(97)00130-7