THE ASSOCIATION OF KNEE INJURY AND OBESITY WITH UNILATERAL AND BILATERAL OSTEOARTHRITIS OF THE KNEE

The strength of the associations of knee injury and obesity with osteoarthritis of the knee was studied for 3,885 adults aged 45–74 years who received knot x-rays in the First National Health and Nutrition Examination Survey, 1971–1975 Bilateral osteoarthritis was more prevalent (5%) than unilateral...

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Bibliographic Details
Published in:American journal of epidemiology 1989-08, Vol.130 (2), p.278-288
Main Authors: DAVIS, MARADEE A., ETTINGER, WALTER H., NEUHAUS, JOHN M., CHO, SANGSOOK A., HAUCK, WALTER W.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
knee injuries
Knee Injuries - complications
Knee Injuries - epidemiology
Knee Joint
Male
Medical sciences
Middle Aged
obesity
Obesity - complications
Obesity - epidemiology
Osteoarthritis
Osteoarthritis - diagnostic imaging
Osteoarthritis - etiology
Radiography
Sex Factors
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Summary:The strength of the associations of knee injury and obesity with osteoarthritis of the knee was studied for 3,885 adults aged 45–74 years who received knot x-rays in the First National Health and Nutrition Examination Survey, 1971–1975 Bilateral osteoarthritis was more prevalent (5%) than unilateral osteoarthritis (2%). Bilateral osteoarthritis was twice as prevalent in women as in men; however there was no sex difference in the prevalence of unilateral osteoarthritis. Odds ratios calculated by means of polychotomous logistic regression indicated thai obesity, knee injury, and age were significantly associated with both unilatera and bilateral knee osteoarthritis. Obesity was a stronger predictor of bilatera osteoarthritis than was knee injury (odds ratio (OR)=6.6 for obesity, 3.5 for right knee injury, and 3.0 for left knee injury; 95% confidence interval (Cl) 4.71-9.18 1.80-6.83, and 1.51-6.11, respectively). Knee injury was a stronger predictor ol unilateral osteoarthritis than was obesity (OR=3.4 and 2.4 for obesity in the right and left knee, respectively (95% Cl 1.55-7.29 and 0.96-5.75) and OR=16.3 and 10.9 for injury in the right and left knee, respectively (95% Cl 6.50-40.89 and 3.72-31.93)). These findings suggest that different pathogenetic processes may exist for unilateral and bilateral knee osteoarthritis.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a115334