The mononuclear cell infiltrate compared with survival in high-grade astrocytomas

Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostl...

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Bibliographic Details
Published in:Acta neuropathologica 1989-01, Vol.78 (2), p.189-193
Main Authors: ROSSI, M. L, JONES, N. R, CANDY, E, NICOLL, J. A. R, COMPTON, J. S, HUGHES, J. T, ESIRI, M. M, MOSS, T. H, CRUZ-SANCHEZ, F. F, COAKHAM, H. B
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Astrocytoma - immunology
Astrocytoma - mortality
Biological and medical sciences
Humans
Lymphocytes - pathology
Macrophages - pathology
Medical sciences
Neurology
Tumors of the nervous system. Phacomatoses
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Summary:Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostly of the CD8 phenotype were also seen in moderate numbers in 70% of cases. CD4-positive cells were present in small numbers in 32% and B cells were seen in only 8% of cases. Analysis of the survival showed no demonstrable correlation between the numbers of macrophages or CD4 lymphocytes and survival. The survival curves for parenchymal CD8 infiltration diverged after 9 months suggesting increased survival for those patients without such an infiltration but the difference failed to reach statistical significance (P = 0.37). No correlation between lymphocytic cuffing and survival was seen after studying all paraffin-embedded material. We conclude that there is no significant statistical correlation between survival and the various types of mononuclear cell infiltrating malignant astrocytomas.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00688208