SUSCEPTIBILITIES OF BACTERIA ISOLATED FROM PATIENTS WITH RESPIRATORY INFECTIOUS DISEASES TO ANTIBIOTICS (1995)

• Published in: Japanese journal of antibiotics 1997/05/25, Vol.50(5), pp.421-459
• Main Authors: IKEMOTO, HIDEO, WATANABE, KAZUYOSHI, MORI, TAKESHI, IGARI, JUN, OGURI, TOYOKO, KAWAGUCHI, HIDEAKI, SHIMIZU, YOSHINORI, MATSUMIYA, HIDEMI, SAITO, AKIRA, TERAI, TSUGIO, INOUE, HIROSHI, NAKADATE, TOSHIHIDE, ITO, CHUICHI, YOSIDA, TAKESI, TANNO, YASUO, OHNO, ISAO, NISHIOKA, KIYO, ARAKAWA, MASAAKI, IGARASHI, KENICHI, WADA, KOUICHI, OKADA, MASAHIKO, OZAKI, KYOKO, AOKI, NOBUKI, KITAMURA, NOBUKO, SEKINE, OSAMU, SUZUKI, YASUTOSHI, MATSUDA, MASAFUMI, TANIMOTO, HIROICHI, NAKATA, KOUICHIRO, NAKATANI, TATSUO, INAGAWA, HIROKO, KABE, JUNZABUROU, KUDO, KOUICHIRO, YAMAMOTO, YUMIKO, ISHIHARA, TERUO, OKADA, JUN, KOBAYASHI, HIROYUKI, KAWAI, SHIN, TAKAYASU, SATOSHI, TAKEDA, HIROAKI, SHIMADA, KAORU, YAMAGUCHI, KEIZO, MATSUMOTO, TETSUYA, IWATA, MORIHIRO, KASHITANI, FUSAKO, ITO, AKIRA, SUMITOMO, MIDORI, KAKU, MITSUO, MATSUSHIMA, TOSHIHARU, NIKI, YOSHIHITO, SOEJIMA, RINZO, ANDO, MASAYUKI, YAMANE, NOBUHISA, TOSAKA, MASAKAZU, KOHNO, SHIGERU, TANAKA, HIRONORI, HIRAKATA, YOICHI, MATSUDA, JUNICHI, NASU, MASARU, ITO, MORIO, YAMAZAKI, TOURU, NAKANO, TADAO, SAITO, ATSUSHI, KUSANO, NOBUCHIKA, TOUYAMA, MASATO
• Format: Article
• Language: Japanese
• Subjects: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacteria - isolation & purification; Child; Child, Preschool; Drug Resistance, Microbial; Female; Humans; Infant; Male; Middle Aged; Respiratory Tract Infections - microbiology; Time Factors
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.50.421

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, since 1981. IKEMOTO et al. have been investigating susceptibilities of these isolates to various antibacterial agents and antibiotics, and characteristics of the patients and isolates from them each year. Results obtained from these investigations are discussed In 23 institutions around the entire Japan, 567 strains of presumably etiological bacteria were isolated mainly from the sputa of 459 patients with lower respiratory tract infections during the period from October 1995 to September 1996. MICs of various antibacterial agents and antibiotics were determined against 74 strains of Staphylococcus aureus, 82 strains of Streptococcus pneumoniae, 104 strains of Haemophilus influenzae, 85 strains of Pseudomonas aeruginosa (non-mucoid strains), 18 strains of Pseudomonas aeruginosa (mucoid strains), 52 strains of Moraxella subgenus Branham-ella catarrhalis, 25 strains of Klebsiella pneumoniae etc., and the drug sceptibilities of these strains were assessed except for those strains that died during ransportation. 1) S. aureus S. aureus strains for which MICs of oxacillin (MPIPC) were higher than 4μg/ml (methicillin-resistant S. aureus) accounted for 52.7%. Arbekacin (ABK) showed the most highest activity against S. aureus with MIC80, of 0.5μg/ml. Vancomycin (VCM) showed the next highest activity with MIC80, of 1μg/ml. These drugs showed the high activities against MRSA with MIC80s of 1μg/ml. 2) S. pneumoniae Most of drugs tested showed potent activities against S. pneumoniae. Imipenem (IPM) and panipenem (PAPM), carbapenems, showed the most potent activitiy with MIC80s of 0.063μg/ml. Cefotaxime (CTX), cefmenoxime (CMX) and cefpirome (CPR) of cephems showed the next most potent activities with MIC80s of 0.25μg/ml. Erythromycin (EM) and clindamycin (CLDM) showed low activities with MIC80s 128μg/ml or high. Among these strains, however, 48.8% and 65.9% of respective strains were quite toward sensitive these agents with MICs of 0.063μg/ml. 3) H. influenzae The activities of all drugs were potent against H. influenzae tested with all MICs at 4μg/ml or below. Cefotiam (CTM), CMX, cefditoren (CDTR) and ofloxacin (OFLX) showed the most potent activity with MIC90s of 0.063μg/ml. 4) P. aeruginosa (mucoid strains) IPM and tobramycin (TOB) showed the most potent activity against P. aeruginosa (mucoid strains) with MIC80s of 1μg/ml. Ceftaz