USE OF ATRACURIUM OR VECURONIUM TO PROLONG THE ACTION OF TUBOCURARINE

Forty patients received tubocurarine in a dose greater than ED90. When neuromuscular function had recovered to amplitude of the first contraction of the train-of-four equals 10% of control, a small increment of atracurium or vecuronium was administered, repeating the same increment at each subsequen...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1989-06, Vol.62 (6), p.659-663
Main Authors: MIDDLETON, C.M., POLLARD, B.J., HEALY, T.E.J., KAY, B.
Format: Article
Language:English
Subjects:
Adult
Anesthetics. Neuromuscular blocking agents
Atracurium - administration & dosage
Biological and medical sciences
Drug Administration Schedule
Humans
Medical sciences
Neuromuscular Junction - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Time Factors
Tubocurarine
Vecuronium Bromide - administration & dosage
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Summary:Forty patients received tubocurarine in a dose greater than ED90. When neuromuscular function had recovered to amplitude of the first contraction of the train-of-four equals 10% of control, a small increment of atracurium or vecuronium was administered, repeating the same increment at each subsequent recovery to 10%. The intensity and duration of the neuromuscular block following the first increment was always greater than that of subsequent increments. The duration and intensity of the block was progressively reduced with subsequent increments until the responses to further increments were unchanged. These final means at steady state were: group 1 (atracurium 1.1 mg) 6.4 (0.3) min; group 2 (atracurium 2.0 mg) 8.2 (0.9) min; group 3 (vecuronium 0.25 mg) 5.8 (0.4) min; group 4 (vecuronium 0.5 mg) 13.2 (0.4) min.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/62.6.659