Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

The serotonin agonist m-chlorophenylpiperazine (m-CPP) had greater anxiogenic and other mood and cognitive effects when administered intravenously (0.1 mg/kg) rather than orally (0.5 mg/kg) to healthy subjects. Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were...

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Bibliographic Details
Published in:Psychopharmacologia 1989-06, Vol.98 (2), p.275-282
Main Authors: MURPHY, D. L, MUELLER, E. A, HILL, J. L, TOLLIVER, T. J, JACOBSEN, F. M
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Affect - drug effects
Anxiety - chemically induced
Behavior - drug effects
Biological and medical sciences
Body Temperature - drug effects
Double-Blind Method
Emotions - drug effects
Female
Humans
Hydrocortisone - blood
Injections, Intravenous
Male
Medical sciences
Neuropharmacology
Neurosecretory Systems - drug effects
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Piperazines - administration & dosage
Piperazines - pharmacology
Prolactin - blood
Random Allocation
Serotoninergic system
Sex Factors
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Summary:The serotonin agonist m-chlorophenylpiperazine (m-CPP) had greater anxiogenic and other mood and cognitive effects when administered intravenously (0.1 mg/kg) rather than orally (0.5 mg/kg) to healthy subjects. Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were obtained with the two dosage regimens, and temperature elevations were greater after oral m-CPP. Plateau phase plasma concentrations of m-CPP at the times of the maximum neuroendocrine responses to intravenous and oral m-CPP were similar. Since all rodent and nonhuman primate studies have used parenterally administered m-CPP, and previous clinical investigations using intravenous rather than oral m-CPP have yielded somewhat discrepant results, our normative data should be useful for comparing results across different human studies and across species.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00444705