Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM

Plasma leptin level is known to correlate with the degree of obesity. To determine the influences of renal function and insulin resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic clamp studies in 57 patients with non-i...

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Bibliographic Details
Published in:Diabetologia 1997-06, Vol.40 (6), p.676-679
Main Authors: SHOJI, T, NISHIZAWA, Y, EMOTO, M, MAEKAWA, K, HIURA, Y, TANAKA, S, KAWAGISHI, T, OKUNO, Y, MORII, H
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adipose Tissue - anatomy & histology
Adult
Aged
Biological and medical sciences
Blood Glucose - metabolism
Body Mass Index
Creatinine - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glucose Clamp Technique
Humans
Insulin - administration & dosage
Insulin - blood
Insulin - pharmacology
Insulin Resistance
Kidney - physiopathology
Leptin
Male
Medical sciences
Middle Aged
Proteins - analysis
Proteins - metabolism
Radioimmunoassay
Regression Analysis
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Summary:Plasma leptin level is known to correlate with the degree of obesity. To determine the influences of renal function and insulin resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic clamp studies in 57 patients with non-insulin-dependent diabetes mellitus with a wide range of renal function. In simple regression analyses, plasma leptin concentration showed significant positive correlations with percentage of body fat measured by dual energy X-ray absorptiometry, body mass index, waist to hip ratio and fasting plasma insulin. Leptin level was higher in females than males. Multiple regression analyses indicated that percent body fat, waist to hip ratio, plasma insulin, gender and renal function (1/creatinine), but not insulin sensitivity, were significant and independent determinants of plasma leptin level. These results suggest that plasma leptin level is regulated or affected by multiple factors including renal function. Insulin resistance appeared to increase leptin levels indirectly by raising plasma insulin.
ISSN:0012-186X
1432-0428
DOI:10.1007/s001250050733