Mechanisms of invasion and lymphatic penetration in human colorectal cancer

The invasive areas in 24 unselected human colorectal cancers were examined by light and electron microscopy and it was shown that the invasive process involves tubes of cells rather than single cells, that degenerative changes take place in specialized cells ahead of the invasive cancer cells and th...

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Bibliographic Details
Published in:Clinical & experimental metastasis 1989-09, Vol.7 (5), p.507-516
Main Authors: Carr, I, Watson, P, Pettigrew, N M
Format: Article
Language:English
Subjects:
Colorectal Neoplasms - pathology
Colorectal Neoplasms - ultrastructure
Endothelium - pathology
Endothelium - ultrastructure
Humans
Lymphatic Metastasis - ultrastructure
Lymphatic System - pathology
Lymphatic System - ultrastructure
Neoplasm Invasiveness
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Summary:The invasive areas in 24 unselected human colorectal cancers were examined by light and electron microscopy and it was shown that the invasive process involves tubes of cells rather than single cells, that degenerative changes take place in specialized cells ahead of the invasive cancer cells and that the endothelium of the lymphatic vessels disintegrates, leaving gaps in the endothelial lining.
ISSN:0262-0898
1573-7276
DOI:10.1007/bf01753811