Localized fibrous tumor (localized fibrous mesothelioma) of the liver

A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Str...

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Bibliographic Details
Published in:Cancer 1989-09, Vol.64 (5), p.1096-1102
Main Authors: Kottke‐Marchant, Kandice, Hart, William R., Broughan, Thomas
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antigens, Neoplasm - analysis
Biological and medical sciences
Cell Nucleus - pathology
Cytoplasm - pathology
Cytoskeletal Proteins - analysis
Desmin - analysis
Desmoplakins
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Keratins - analysis
Liver Neoplasms - analysis
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Membrane Glycoproteins - analysis
Mesothelioma - analysis
Mesothelioma - diagnostic imaging
Mesothelioma - pathology
Microscopy, Electron
Mucin-1
Tomography, X-Ray Computed
Tumors
Vimentin - analysis
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Summary:A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1‐3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow‐up information has been limited.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19890901)64:5<1096::AID-CNCR2820640521>3.0.CO;2-0