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Localized fibrous tumor (localized fibrous mesothelioma) of the liver
A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Str...
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| Published in: | Cancer 1989-09, Vol.64 (5), p.1096-1102 |
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| Language: | English |
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| container_end_page | 1102 |
| container_issue | 5 |
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| container_title | Cancer |
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| creator | Kottke‐Marchant, Kandice Hart, William R. Broughan, Thomas |
| description | A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1‐3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow‐up information has been limited. |
| doi_str_mv | 10.1002/1097-0142(19890901)64:5<1096::AID-CNCR2820640521>3.0.CO;2-0 |
| format | article |
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The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1‐3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow‐up information has been limited.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19890901)64:5<1096::AID-CNCR2820640521>3.0.CO;2-0</identifier><identifier>PMID: 2474368</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Antigens, Neoplasm - analysis ; Biological and medical sciences ; Cell Nucleus - pathology ; Cytoplasm - pathology ; Cytoskeletal Proteins - analysis ; Desmin - analysis ; Desmoplakins ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoenzyme Techniques ; Keratins - analysis ; Liver Neoplasms - analysis ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Membrane Glycoproteins - analysis ; Mesothelioma - analysis ; Mesothelioma - diagnostic imaging ; Mesothelioma - pathology ; Microscopy, Electron ; Mucin-1 ; Tomography, X-Ray Computed ; Tumors ; Vimentin - analysis</subject><ispartof>Cancer, 1989-09, Vol.64 (5), p.1096-1102</ispartof><rights>Copyright © 1989 American Cancer Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4801-cadf274261b04ec15f07cdb9a2b485324f25f54430665f50c98b1923d9fd321c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7298312$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2474368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kottke‐Marchant, Kandice</creatorcontrib><creatorcontrib>Hart, William R.</creatorcontrib><creatorcontrib>Broughan, Thomas</creatorcontrib><title>Localized fibrous tumor (localized fibrous mesothelioma) of the liver</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1‐3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow‐up information has been limited.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - pathology</subject><subject>Cytoplasm - pathology</subject><subject>Cytoskeletal Proteins - analysis</subject><subject>Desmin - analysis</subject><subject>Desmoplakins</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Keratins - analysis</subject><subject>Liver Neoplasms - analysis</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>Mesothelioma - analysis</subject><subject>Mesothelioma - diagnostic imaging</subject><subject>Mesothelioma - pathology</subject><subject>Microscopy, Electron</subject><subject>Mucin-1</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Vimentin - analysis</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqVkFFrFDEUhYModVv9CcI8iLQPs97cZDLJVoQyVi0sLoiC4MMlk0lwZKZTk11L_fVm2XVBBcGn3HvPyeHwMdZwmHMAfM7B1CVwiafcaAMG-JmSi-pFvqvF4uLqVdm8a96jRlASKuQvxRzmzeocS7jHZoff99kMAHRZSfHpITtO6Wtea6zEETtCWUuh9IxdLidnh_6H74rQt3HapGK9GadYnA5_CaNP0_qLH_pptGfFFIq8FEP_3cdH7EGwQ_KP9-8J-_j68kPztlyu3lw1F8vSSQ28dLYLWEtUvAXpHa8C1K5rjcVW6kqgDFiFSkoBSuUBnNEtNyg6EzqB3IkT9myXexOnbxuf1jT2yflhsNc-N6TacDRG19n4eWd0cUop-kA3sR9tvCMOtIVMW0y0xUS_IJOSVG3viihDpt8hkyCgZkVIkNOf7Gts2tF3h-w91aw_3es2ZYgh2mvXp4OtRqMFx2wLO9ttP_i7_2v4z4J_KOIn0TmlNw</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Kottke‐Marchant, Kandice</creator><creator>Hart, William R.</creator><creator>Broughan, Thomas</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Localized fibrous tumor (localized fibrous mesothelioma) of the liver</title><author>Kottke‐Marchant, Kandice ; Hart, William R. ; Broughan, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4801-cadf274261b04ec15f07cdb9a2b485324f25f54430665f50c98b1923d9fd321c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleus - pathology</topic><topic>Cytoplasm - pathology</topic><topic>Cytoskeletal Proteins - analysis</topic><topic>Desmin - analysis</topic><topic>Desmoplakins</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Keratins - analysis</topic><topic>Liver Neoplasms - analysis</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>Mesothelioma - analysis</topic><topic>Mesothelioma - diagnostic imaging</topic><topic>Mesothelioma - pathology</topic><topic>Microscopy, Electron</topic><topic>Mucin-1</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><topic>Vimentin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kottke‐Marchant, Kandice</creatorcontrib><creatorcontrib>Hart, William R.</creatorcontrib><creatorcontrib>Broughan, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kottke‐Marchant, Kandice</au><au>Hart, William R.</au><au>Broughan, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localized fibrous tumor (localized fibrous mesothelioma) of the liver</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>64</volume><issue>5</issue><spage>1096</spage><epage>1102</epage><pages>1096-1102</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83‐year‐old woman is presented. The tumor was 15 × 9 × 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high‐power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1‐3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow‐up information has been limited.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2474368</pmid><doi>10.1002/1097-0142(19890901)64:5<1096::AID-CNCR2820640521>3.0.CO;2-0</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer, 1989-09, Vol.64 (5), p.1096-1102 |
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| language | eng |
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| subjects | Aged Aged, 80 and over Antigens, Neoplasm - analysis Biological and medical sciences Cell Nucleus - pathology Cytoplasm - pathology Cytoskeletal Proteins - analysis Desmin - analysis Desmoplakins Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Keratins - analysis Liver Neoplasms - analysis Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Membrane Glycoproteins - analysis Mesothelioma - analysis Mesothelioma - diagnostic imaging Mesothelioma - pathology Microscopy, Electron Mucin-1 Tomography, X-Ray Computed Tumors Vimentin - analysis |
| title | Localized fibrous tumor (localized fibrous mesothelioma) of the liver |
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