Fibrous dysplasia of the skull with acromegaly and sarcomatous transformation. Two cases with a review of the literature

Two cases of fibrous dysplasia of the skull are reported. Both patients were young women with acromegaly and were treated with radiotherapy. Progressive pareses of cranial nerves, pain, and a malignant course of the disease were characteristic in both patients, and the diagnosis of osteogenous sarco...

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Bibliographic Details
Published in:Journal of neuro-oncology 1989-05, Vol.7 (1), p.25-29
Main Authors: MORTENSEN, A, BOJSEN-MOLLER, M, RASMUSSEN, P
Format: Article
Language:English
Subjects:
Acromegaly - complications
Acromegaly - radiotherapy
Adult
Biological and medical sciences
Female
Fibrous Dysplasia of Bone - complications
Fibrous Dysplasia of Bone - physiopathology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Osteosarcoma - etiology
Osteosarcoma - pathology
Osteosarcoma - radiotherapy
Skull Neoplasms - etiology
Skull Neoplasms - pathology
Skull Neoplasms - radiotherapy
Citations: Items that this one cites
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Description
Summary:Two cases of fibrous dysplasia of the skull are reported. Both patients were young women with acromegaly and were treated with radiotherapy. Progressive pareses of cranial nerves, pain, and a malignant course of the disease were characteristic in both patients, and the diagnosis of osteogenous sarcoma proved in one of them by histological examination. The clinical picture of fibrous dysplasia of the skull and the role of radiotherapy with the risk of development of malignancy is discussed.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00149375