Serum bactericidal activity of ceftazidime administered as continuous infusion of 3 g over 24 h versus intermittent bolus infusion of 2 g against Pseudomonas aeruginosa in healthy volunteers

Continuous infusion of beta -lactams has been advocated as an alternative method of administration, since beta -lactams demonstrate concentration-independent bactericidal activity and do not have an appreciable post-antibiotic effect especially against Gram-negative bacteria. In addition, the length...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1997-06, Vol.39 (6), p.841-842
Main Authors: Lemmen, S W, Engels, I, Daschner, F D
Format: Article
Language:English
Subjects:
Ceftazidime - administration & dosage
Cephalosporins - administration & dosage
Humans
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - blood
Pseudomonas Infections - drug therapy
Serum Bactericidal Test
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Summary:Continuous infusion of beta -lactams has been advocated as an alternative method of administration, since beta -lactams demonstrate concentration-independent bactericidal activity and do not have an appreciable post-antibiotic effect especially against Gram-negative bacteria. In addition, the length of time that beta -lactam concentration remains above the MIC appears to be the best parameter for predicting successful treatment.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/39.6.841b