Middle cerebral artery occlusion in rats studied by magnetic resonance imaging

Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion def...

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Bibliographic Details
Published in:Stroke (1970) 1989-08, Vol.20 (8), p.1032-1036
Main Authors: BRADLEY, R. H, KENT, T. A, EISENBERG, H. M, QUAST, M. J, WARD, G. A, CAMPBELL, G. A, HILLMAN, G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Cerebral Arterial Diseases - complications
Constriction
Contrast Media
Ferric Compounds
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - etiology
Magnetic Resonance Imaging
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Rats
Rats, Inbred Strains
Subtraction Technique
Time Factors
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Summary:Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 hour after occlusion, earlier than conventional T2-weighted images. The area of altered perfusion detected by this technique (subtraction imaging after AMI-25 administration) correlated with that demonstrated by iodoantipyrine autoradiography. Since this magnetic resonance technique can be used to serially estimate the location and size of the ischemic area, the technique can be an important adjunct to metabolic studies of focal ischemia using magnetic resonance spectroscopy. The technique may have clinical applications as well.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.20.8.1032