Lymphocyte subset abnormalities in canine leishmaniasis

Peripheral blood lymphocyte subpopulations were studied in 42 Leishmania infantum-infected dogs using flow cytometry. Twenty-two healthy dogs were used as a control group. Analysis of the B-cell populations showed a reduction in the number of CD21 + cells in all the infected dogs. On the other hand,...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 1997-05, Vol.56 (3), p.345-351
Main Authors: Bourdoiseau, G., Bonnefont, C., Magnol, J.P., Saint-André, I., Chabanne, L.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocyte Subsets - immunology
Dog Diseases - blood
Dog Diseases - etiology
Dog Diseases - immunology
Dogs
Female
Flow Cytometry
Leishmania infantum
Leishmaniasis, Visceral - blood
Leishmaniasis, Visceral - immunology
Leishmaniasis, Visceral - veterinary
Lymphocyte
Lymphocyte Subsets - immunology
Male
T-Lymphocyte Subsets - immunology
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Summary:Peripheral blood lymphocyte subpopulations were studied in 42 Leishmania infantum-infected dogs using flow cytometry. Twenty-two healthy dogs were used as a control group. Analysis of the B-cell populations showed a reduction in the number of CD21 + cells in all the infected dogs. On the other hand, the disease was found to be associated with a striking decrease in the number of CD21 + cells and of T-lymphocyte CD4 + cells in comparison with asymptomatic dogs and with healthy dogs. This study suggests that the dysimmunity which is observed with leishmaniasis may be linked to a reduced number of T-lymphocyte CD4 + cells.
ISSN:0165-2427
1873-2534
DOI:10.1016/S0165-2427(96)05768-6