Distribution of T-cell signalling molecules in human myeloma

It is controversial whether altered levels of TCR/CD3-associated signalling molecules play a role in the T-cell dysfunction of cancer patients. In multiple myeloma (MM), peripheral blood T (PBT) lymphocytes are functionally impaired by prolonged exposure to tumour cells, and so we investigated the o...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 1997-06, Vol.97 (4), p.815-820
Main Authors: BIANCHI, A, MARIANI, S, BEGGIATO, E, BORRIONE, P, PEOLA, S, BOCCADORO, M, PILERI, A, MASSAIA, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Communication - immunology
Hematologic and hematopoietic diseases
Humans
Isoenzymes - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Medical sciences
Multiple Myeloma - immunology
Phospholipase C gamma
Protein Kinase C - metabolism
Protein Kinase C-alpha
Protein-Tyrosine Kinases - metabolism
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-fyn
Receptor-CD3 Complex, Antigen, T-Cell - metabolism
Signal Transduction - physiology
T-Lymphocytes - immunology
Type C Phospholipases - metabolism
ZAP-70 Protein-Tyrosine Kinase
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is controversial whether altered levels of TCR/CD3-associated signalling molecules play a role in the T-cell dysfunction of cancer patients. In multiple myeloma (MM), peripheral blood T (PBT) lymphocytes are functionally impaired by prolonged exposure to tumour cells, and so we investigated the organization of the TCR/CD3-associated signal transduction machinery. The aim of this study was two-fold: first, to investigate the levels of CD3zeta, p56(lck), p59(fyn), ZAP-70, protein kinase C-alpha (PKC-alpha) and phospholipase C-gamma (PLC-gamma) in MM PBT cells; second, to determine whether levels of expression were correlated with clinical or prognostic factors. Forty-four MM patients were studied and 25 age-matched normal donors served as controls. On average, PKC-alpha was the only significantly decreased (P
ISSN:0007-1048
1365-2141