Indium-111 pentetreotide single-photon emission tomography in patients with TSH-secreting pituitary adenomas : correlation with the effect of a single administration of octreotide on serum TSH levels

Few data are available on the visualization of somatostatin receptors in vivo in patients with thyrotropin (TSH)-secreting adenoma. We studied five patients with TSH-secreting adenomas using single-photon emission tomography (SPET) after administration of indium-111 pentetreotide. The intensity of 1...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1997-07, Vol.24 (7), p.728-731
Main Authors: LOSA, M, MAGNANI, P, MORTINI, P, PERSANI, L, ACERNO, S, GIUGNI, E, SONGINI, C, FAZIO, F, BECK-PECCOZ, P, GIOVANELLI, M
Format: Article
Language:English
Subjects:
Adenoma - chemistry
Adenoma - diagnostic imaging
Adenoma - metabolism
Adult
Biological and medical sciences
Endocrine glands. Genital system. Mammary gland
Female
Hormones - pharmacology
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Octreotide - pharmacology
Pituitary Neoplasms - chemistry
Pituitary Neoplasms - diagnostic imaging
Pituitary Neoplasms - metabolism
Radionuclide investigations
Receptors, Somatostatin - analysis
Somatostatin - analogs & derivatives
Thyrotropin - blood
Thyrotropin - drug effects
Thyrotropin - metabolism
Tomography, Emission-Computed, Single-Photon
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Summary:Few data are available on the visualization of somatostatin receptors in vivo in patients with thyrotropin (TSH)-secreting adenoma. We studied five patients with TSH-secreting adenomas using single-photon emission tomography (SPET) after administration of indium-111 pentetreotide. The intensity of 111In-pentetreotide uptake by the tumours was correlated with the degree of TSH suppression after a single administration of 100 microg octreotide s. c. Five patients (three women and two men) aged 27-46 years were investigated. Except for one patient with acromegaly, all had pure TSH-secreting tumours. One patient was previously untreated, while two had received octreotide, one antithyroid drugs, and one radioiodine. In all patients SPET demonstrated increased uptake of 111In-pentetreotide by the pituitary adenoma. The target to non-target ratio (T/nT) of 111In-pentetreotide uptake was higher than 10 in three patients. Administration of 100 microg octreotide s. c. caused a significant reduction in TSH levels from 4.8+/-1.4 mU/l to a nadir of 3.1+/-1.1 mU/l after 6 h (P
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00879659