Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts

• Published in: The Journal of pharmacology and experimental therapeutics 1997-07, Vol.282 (1), p.363-368
• Main Authors: Brunvand, H, Grong, K
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Antagonists - pharmacology; Animals; Carbazoles - pharmacology; Cardiac Output - drug effects; Cats; Coronary Circulation - drug effects; Male; Myocardial Contraction - drug effects; Myocardial Ischemia - physiopathology; Propanolamines - pharmacology; Vasodilator Agents - pharmacology
• ISSN: 0022-3565; 1521-0103

The purpose of our study was to investigate whether loss of myocardial contraction immediately after coronary occlusion was nonuniform, and if pretreatment with carvedilol, a vasodilating nonselective β-adrenoceptor antagonist, could retard loss of contraction after coronary artery occlusion. Feline hearts were subjected to acute regional ischemia by total occlusion of the left anterior descending coronary artery. The animals were either treated with vehicle (control group) or with carvedilol 1 mg/kg i.v. before left anterior descending coronary artery occlusion ( n = 9 in each group). Regional contraction in the left anterior descending coronary artery perfused region of the heart was studied by cross-oriented sonomicrometry. In control animals, circumferential (subepicardial) contraction ceased after 10 sec, whereas longitudinal (subendocardial) contraction ceased immediately after left anterior descending coronary artery occlusion. Loss of contraction in animals treated with carvedilol was significantly slower compared to controls. Circumferential contraction ceased between 30 sec and 1 min, whereas longitudinal contraction ceased after 20 sec. In conclusion, loss of contraction during the first seconds after coronary occlusion was nonuniform, with most rapid dysfunction in the subendocardium. Pretreatment with carvedilol retarded loss of contraction in both axes.