The distribution of a dopamine D2 receptor mRNA in rat brain

Based on the recently reported sequence of a dopamine D2 receptor cloned from rat brain, we prepared a series of cDNA probes to determine the distribution of mRNA encoding this receptor. Within the forebrain, D2 receptor mRNA is abundant in the caudate-putamen, accumbens nucleus and olfactory tuberc...

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Bibliographic Details
Published in:FEBS letters 1989-08, Vol.253 (1), p.207-213
Main Authors: Weiner, David M., Brann, Mark R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Northern
Brain - anatomy & histology
Brain - physiology
Brain Mapping
Cell receptors
Cell structures and functions
Dopamine receptor
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Molecular and cellular biology
Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)
mRNA
Neurotransmitter receptor
Nucleic Acid Hybridization
Oligonucleotide Probes
Rats
Receptors, Dopamine - genetics
RNA, Messenger - genetics
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Summary:Based on the recently reported sequence of a dopamine D2 receptor cloned from rat brain, we prepared a series of cDNA probes to determine the distribution of mRNA encoding this receptor. Within the forebrain, D2 receptor mRNA is abundant in the caudate-putamen, accumbens nucleus and olfactory tubercle. Moderate to low levels of mRNA are observed in the medial habenular nucleus, diagonal band, lateral septal nucleus, claustrum, dorsal endopiriform nucleus, and entorhinal cortex. In the mesencephalon, D2 receptor mRNA is abundant within the substantia nigra, pars compacta, and the ventral tegmental area. Comparison of the distributions of the mRNA and ligand binding indicates that both presynaptic and postsynaptic D2 receptors of the nigrostriatal, mesolimbic and mesocortical pathways are derived from the same mRNA.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80960-3