Biologically active casein peptides implicated in immunomodulation

Maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance t...

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Bibliographic Details
Published in:Journal of dairy research 1989-01, Vol.56 (3), p.357-362
Main Authors: Migliore-Samour, D, Floc'h, F, Jolles, P
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - immunology
casein
Caseins - analysis
Cattle
Humans
Infant, Newborn - immunology
Klebsiella Infections - immunology
Klebsiella pneumoniae
Mice
Oligopeptides - immunology
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Original Articles
peptides
Phagocytosis - drug effects
protein digestion
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Summary:Maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. These data suggest that casein peptides may exert a stimulating function on the immune system of the newborn.
ISSN:0022-0299
1469-7629
DOI:10.1017/S0022029900028806