Biologically active casein peptides implicated in immunomodulation

Maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance t...

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Published in:Journal of dairy research 1989-01, Vol.56 (3), p.357-362
Main Authors: Migliore-Samour, D, Floc'h, F, Jolles, P
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - immunology
casein
Caseins - analysis
Cattle
Humans
Infant, Newborn - immunology
Klebsiella Infections - immunology
Klebsiella pneumoniae
Mice
Oligopeptides - immunology
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Original Articles
peptides
Phagocytosis - drug effects
protein digestion
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cites cdi_FETCH-LOGICAL-c527t-210032dca4f1638ba2d4035ab66fed03d4105d0012c05dc3c0e565a24ea901f43
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container_issue 3
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container_title Journal of dairy research
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creator Migliore-Samour, D
Floc'h, F
Jolles, P
description Maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. These data suggest that casein peptides may exert a stimulating function on the immune system of the newborn.
doi_str_mv 10.1017/S0022029900028806
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Breastfeeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. Among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. Corresponding synthetic peptides stimulated in vitro phagocytic activity of murine and of human macrophages and exerted in vivo a protective effect against Klebsiella pneumoniae infection of mice. 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ispartof Journal of dairy research, 1989-01, Vol.56 (3), p.357-362
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source Cambridge University Press:JISC Collections:Full Collection Digital Archives (STM and HSS) (218 titles)
subjects Animals
Animals, Newborn - immunology
casein
Caseins - analysis
Cattle
Humans
Infant, Newborn - immunology
Klebsiella Infections - immunology
Klebsiella pneumoniae
Mice
Oligopeptides - immunology
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Original Articles
peptides
Phagocytosis - drug effects
protein digestion
title Biologically active casein peptides implicated in immunomodulation
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