A hybrid carcinoma : adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland : An immunohistochemical study

Hybrid tumours of the salivary glands are very rare entities composed of two different tumours, each of which conforms with an exactly defined category. We describe an unusual hybrid carcinoma of the palate; it was comprised of an adenoid cystic carcinoma and a salivary duct carcinoma with a transit...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1997-06, Vol.430 (6), p.495-500
Main Authors: KAMIO, N, TANAKA, Y, MUKAI, M, IKEDA, E, KURAMOCHI, S, FUJII, M, HOSODA, Y
Format: Article
Language:English
Subjects:
Actins - analysis
Antibodies, Neoplasm - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma, Adenoid Cystic - pathology
Glial Fibrillary Acidic Protein - analysis
Humans
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
S100 Proteins - analysis
Salivary Gland Neoplasms - pathology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Vimentin - analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hybrid tumours of the salivary glands are very rare entities composed of two different tumours, each of which conforms with an exactly defined category. We describe an unusual hybrid carcinoma of the palate; it was comprised of an adenoid cystic carcinoma and a salivary duct carcinoma with a transitional region. These two different compartments showed different characteristics as regards cellular differentiation, proliferative activity, and expression of oncogene and tumour suppressor oncogene proteins, as revealed by using markers for muscle actin, keratin, vimentin, S-100 protein, GFAP, Ki-67, p53, and c-erbB-2 proteins. This case is the first reported with overexpression of p53 and c-erbB-2 proteins in the tumour entities. Salivary gland tumours consist of heterogeneous histological groups, and each has morphological diversity. This case indicates that some of the oncogene and tumour suppressor oncogene proteins may help to produce the histological heterogeneity of the salivary gland tumour.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050060