Disposition of Single-Dose Intravenously Administered Enrofloxacin in Emus (Dromaius novaehollandiae)

The pharmacokinetics of enrofloxacin in emus (Dromaius novaehollandiae) were examined following parenteral administration. A mean allometrically scaled dose of 2.2 ± 0.03 mg/kg was administered as a single i.v. bolus, and serum samples were collected at predetermined intervals over a 24-hr period. E...

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Bibliographic Details
Published in:Journal of zoo and wildlife medicine 1997-03, Vol.28 (1), p.43-48
Main Authors: Helmick, Kelly E., Boothe, Dawn Merton, Jensen, James M.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacokinetics
Birds - metabolism
Chickens - metabolism
Dosage
Drug design
Emus
Fluoroquinolones
Half lives
Injections, Intravenous
Intravenous injections
Ostriches
Parrots - metabolism
Pharmacokinetics
Quinolones - pharmacokinetics
Wildlife
Zoos
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Summary:The pharmacokinetics of enrofloxacin in emus (Dromaius novaehollandiae) were examined following parenteral administration. A mean allometrically scaled dose of 2.2 ± 0.03 mg/kg was administered as a single i.v. bolus, and serum samples were collected at predetermined intervals over a 24-hr period. Enrofloxacin levels were measured using high-performance liquid chromatography, and the resulting concentration versus time curve was analyzed using nonlinear regression with least squares parameter estimation. The data were best represented by a two-compartment model with a mean elimination half-life of 3.33 hr. Mean model independent parameters obtained were area under the curve (8.26 μg·hr/ml), mean residence time (4.40 hr), apparent volume of distribution (1.49 L/kg), and total body drug clearance (0.36 L/hr/kg). Mean serum concentrations exceeded the target peak of 2.0 μg/ml and remained above an estimated inhibitory concentration of 0.5 μg/ml for approximately 2 hr. Based upon the results of this study, enrofloxacin administered parenterally to emus at 2.2 mg/kg every 12 hr is expected to achieve therapeutic serum concentrations against susceptible organisms.
ISSN:1042-7260
1937-2825