Twenty two weeks of transdermal estradiol increases sex hormone-binding globulin in surgical menopausal women

Objective: To compare the effects of continuous noncombined transdermal estradiol versus oral conjugated estrogen on serum sex hormone-binding globulin (SHBG) levels prior to and during the 10th and 22nd weeks of therapy in patients with surgical menopause. Study design: Open, comparative trial. Pat...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 1997-06, Vol.73 (2), p.149-152
Main Authors: Başbuǧ, Mustafa, Aygen, Ercan, Tayyar, Mehmet, Muhtaroǧlu, Sebahattin, Demir, İbrahim, Ökten, Süheyl
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Oral
Aged
Biological and medical sciences
Breast cancer
Cardiovascular disease
Conjugated estrogen
Drug Administration Schedule
Estradiol - therapeutic use
Estrogen Replacement Therapy - methods
Female
Hormones. Endocrine system
Humans
Hysterectomy
Medical sciences
Menopause, Premature
Middle Aged
Pharmacology. Drug treatments
Sex hormone-binding globulin
Sex Hormone-Binding Globulin - metabolism
Transdermal estradiol
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Summary:Objective: To compare the effects of continuous noncombined transdermal estradiol versus oral conjugated estrogen on serum sex hormone-binding globulin (SHBG) levels prior to and during the 10th and 22nd weeks of therapy in patients with surgical menopause. Study design: Open, comparative trial. Patients were consecutively assigned to three groups: group 1 ( n = 18) received continuous transdermal estradiol (0.050 mg/day), group 2 ( n = 18) continuous oral conjugated estrogens (0.625 mg/day), whereas group 3 ( n = 15) received no treatment. Serum SHBG levels were determined before treatment and after 10 and 22 weeks of treatment. Results: Serum SHBG increased significantly with oral conjugated estrogens at 10 ( p
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(97)02706-1