Ocular Dominance Column Development: Analysis and Simulation

The visual cortex of many adult mammals has patches of cells that receive inputs driven by the right eye alternating with patches that receive inputs driven by the left eye. These ocular dominance patches (or ``columns'') form during early life as a consequence of competition between the a...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-08, Vol.245 (4918), p.605-615
Main Authors: Miller, Kenneth D., Keller, Joseph B., Stryker, Michael P.
Format: Article
Language:English
Subjects:
Afferent Pathways - physiology
Animals
Biological and medical sciences
Cats
Computer Simulation
Eye - growth & development
Eye - innervation
Eye and associated structures. Visual pathways and centers. Vision
Eyes
Eyes & eyesight
Functional Laterality
Fundamental and applied biological sciences. Psychology
Geniculate Bodies - physiology
Mammals
Mathematical functions
Mathematics
Modeling
Models, Biological
Monoculars
Neurons
Ocular dominance
Ocular Physiological Phenomena
Stripes
Synapses
Synapses - physiology
Vertebrates: nervous system and sense organs
Vision, Ocular - physiology
Visions
Visual cortex
Visual Cortex - growth & development
Visual Cortex - physiology
Wavelengths
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Summary:The visual cortex of many adult mammals has patches of cells that receive inputs driven by the right eye alternating with patches that receive inputs driven by the left eye. These ocular dominance patches (or ``columns'') form during early life as a consequence of competition between the activity patterns of the two eyes. A mathematical model of several biological mechanisms that can account for this development is presented. Analysis of this model reveals the conditions under which ocular dominance segregation will occur and determines the resulting patch width. Simulations of the model also exhibit other phenomena associated with early visual development, such as topographic refinement of cortical receptive fields, the confinement of input cell connections to patches, monocular deprivation plasticity including a critical period, and the effect of artificially induced strabismus. The model can be used to predict the results of proposed experiments and to discriminate among various mechanisms of plasticity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2762813