Prospects for Development of a Rotavirus Vaccine against Rotavirus Diarrhea in Infants and Young Children

Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the "Jennerian" approach,...

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Bibliographic Details
Published in:Reviews of infectious diseases 1989-05, Vol.11, p.S539-S546
Main Authors: Kapikian, Albert Z., Flores, Jorge, Hoshino, Yasutaka, Midthun, Karen, Gorziglia, Mario, Green, Kim Y., Chanock, Robert M., Louis Potash, Stephen D. Sears, Clements, Mary Lou, Halsey, Neal A., Black, Robert E., Irene Perez-Schael
Format: Article
Language:English
Subjects:
Animals
Antibodies
Child, Preschool
Children
Diarrhea
Diarrhea - prevention & control
Diarrhea, Infantile - prevention & control
Diseases
Humans
Infant
Infants
Population
Rotavirus
Rotavirus - immunology
Rotavirus Infections - prevention & control
Rotavirus vaccines
Session III: New Vaccines
Vaccination
Vaccines, Attenuated
Vaccines, Synthetic
Viral Vaccines
Viruses
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Summary:Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the "Jennerian" approach, in which a related live, attenuated rotavirus strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the "Jennerian" approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.
ISSN:0162-0886