Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae

Yeast strains that lack mitochondrial function are sensitive to oxidative stress caused by reactive oxygen species (ROS). Specifically, rho 0 mutants that lack mitochondrial DNA, and strains deleted for the nuclear genes COX6 and COQ3 that are required for function of the respiratory electron transp...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1997-06, Vol.410 (2), p.219-222
Main Authors: Grant, Chris M, MacIver, Fiona H, Dawes, Ian W
Format: Article
Language:English
Subjects:
Coq3
Cox6
Electron Transport
Hydrogen Peroxide - pharmacology
Mitochondria - drug effects
Mitochondria - physiology
Oxidative Stress
Respiration
Respiratory deficient
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Yeast strains that lack mitochondrial function are sensitive to oxidative stress caused by reactive oxygen species (ROS). Specifically, rho 0 mutants that lack mitochondrial DNA, and strains deleted for the nuclear genes COX6 and COQ3 that are required for function of the respiratory electron transport chain, were sensitive to H 2O 2. In addition, treatment with mitochondrial inhibitors including antimycin A, oligomycin, potassium cyanide and sodium azide increased sensitivity to H 2O 2. The mechanism does not appear to depend on the antioxidant status of the cell since respiratory-deficient strains were able to mount an inducible adaptive response to H 2O 2. We suggest that the oxidant sensitivity is due to a defect in an energy-requiring process that is needed for detoxification of ROS or for the repair of oxidatively damaged molecules.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)00592-9