Blood lipoproteins and their effect on contractile function of vessels in rats of different age

Experiments on adult and old rats have shown that blood lipoproteins (LP) exert a dilatatory effect on isolated segments of the thoracic aorta in animals of different age. In old versus adult animals, the sensitivity of vessels in all LP fractions (LDL, VLDL and HDL (low, very low and high density L...

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Bibliographic Details
Published in:Mechanisms of ageing and development 1997-09, Vol.97 (3), p.207-214
Main Authors: Frolkis, V.V, Kulchitsky, O.K, Novikova, S.N, Sikalo, N.V, Potapenko, R.I, Bogatskaya, L.N, Burchinskaya, M.K, Mozzhukhina, T.G
Format: Article
Language:English
Subjects:
Age
Aging - metabolism
Aging - physiology
Animals
Aorta - drug effects
Apolipoproteins
Biological and medical sciences
Blood Vessels - drug effects
Blood vessels and receptors
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
HDL
LDL
Lipoproteins - blood
Lipoproteins - pharmacology
Male
Norepinephrine - pharmacology
Rats
Rats, Wistar
Vertebrates: cardiovascular system
Vessels
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Summary:Experiments on adult and old rats have shown that blood lipoproteins (LP) exert a dilatatory effect on isolated segments of the thoracic aorta in animals of different age. In old versus adult animals, the sensitivity of vessels in all LP fractions (LDL, VLDL and HDL (low, very low and high density LP)) was lower as a result of age changes in the reactivity of vessels. The capacity of HDL to produce a vasodilatatory effect decreases with age, which may be linked to changes in the lipid and apolipoprotein composition. The results revealed a decrease in the level of phospholipids and an increase in the amount of total cholesterol in HDL observed in old age. The capacities of LDL and VLDL to exert a vascular dilatatory action remained unchanged with age.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(97)00060-2