Blood lipoproteins and their effect on contractile function of vessels in rats of different age

• Published in: Mechanisms of ageing and development 1997-09, Vol.97 (3), p.207-214
• Main Authors: Frolkis, V.V, Kulchitsky, O.K, Novikova, S.N, Sikalo, N.V, Potapenko, R.I, Bogatskaya, L.N, Burchinskaya, M.K, Mozzhukhina, T.G
• Format: Article
• Language: English
• Subjects: Age; Aging - metabolism; Aging - physiology; Animals; Aorta - drug effects; Apolipoproteins; Biological and medical sciences; Blood Vessels - drug effects; Blood vessels and receptors; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; HDL; LDL; Lipoproteins - blood; Lipoproteins - pharmacology; Male; Norepinephrine - pharmacology; Rats; Rats, Wistar; Vertebrates: cardiovascular system; Vessels
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/S0047-6374(97)00060-2

Experiments on adult and old rats have shown that blood lipoproteins (LP) exert a dilatatory effect on isolated segments of the thoracic aorta in animals of different age. In old versus adult animals, the sensitivity of vessels in all LP fractions (LDL, VLDL and HDL (low, very low and high density LP)) was lower as a result of age changes in the reactivity of vessels. The capacity of HDL to produce a vasodilatatory effect decreases with age, which may be linked to changes in the lipid and apolipoprotein composition. The results revealed a decrease in the level of phospholipids and an increase in the amount of total cholesterol in HDL observed in old age. The capacities of LDL and VLDL to exert a vascular dilatatory action remained unchanged with age.