Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases

The prognostic significance of cytogenetic abnormalities was determined in 106 patients with well‐characterized idiopathic myelofibrosis who were successfully karyotyped at diagnosis. 35% of the cases exhibited a clonal abnormality (37/106), whereas 65% (69/106) had a normal karyotype. Three charact...

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Bibliographic Details
Published in:British journal of haematology 1997-07, Vol.98 (1), p.96-102
Main Authors: Reilly, J. T., Snowden, J. A., Spearing, R. L., Fitzgerald, P. M., Jones, N., Watmore, A., Potter, A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Chromosome Aberrations
cytogenetics
Female
Hematologic and hematopoietic diseases
Humans
Karyotyping
Male
Medical sciences
Middle Aged
myelofibrosis
Platelet diseases and coagulopathies
Primary Myelofibrosis - genetics
Prognosis
prognostic factors
Risk Factors
Survival Analysis
Survival Rate
Citations: Items that cite this one
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Summary:The prognostic significance of cytogenetic abnormalities was determined in 106 patients with well‐characterized idiopathic myelofibrosis who were successfully karyotyped at diagnosis. 35% of the cases exhibited a clonal abnormality (37/106), whereas 65% (69/106) had a normal karyotype. Three characteristic defects, namely del(13q) (nine cases), del(20q) (eight cases) and partial trisomy 1q (seven cases), were present in 64.8% (24/37) of patients with clonal abnormalities. Kaplan‐Meier plots and log rank analysis demonstrated an abnormal karyotype to be an adverse prognostic variable (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1997.1722990.x