Origins and functions of the chlamydial inclusion

Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 1997-07, Vol.5 (7), p.288-293
Main Authors: Hackstadt, Ted, Fischer, Elizabeth R., Scidmore, Marci A., Rockey, Daniel D., Heinzen, Robert A.
Format: Article
Language:English
Subjects:
Biological Transport, Active
Cell Membrane - metabolism
Chlamydia
Chlamydia Infections - physiopathology
Chlamydia trachomatis - growth & development
Chlamydia trachomatis - physiology
Chlamydia trachomatis - ultrastructure
Endocytosis
Humans
Inclusion Bodies - metabolism
Inclusion Bodies - microbiology
Membrane Fusion
Models, Biological
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Description
Summary:Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(97)01061-5