MHC class II B genes in the channel catfish ( Ictalurus punctatus)

Two different cDNA sequences for major histocompatibility complex (MHC) class II β chains from the channel catfish ( Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles o...

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Bibliographic Details
Published in:Developmental and comparative immunology 1997-01, Vol.21 (1), p.13-23
Main Authors: Godwin, Ulla B., Antao, Aurita, Wilson, Melanie R., Gregory Chinchar, V., Miller, Norman W., William Clem, L., McConnell, Thomas J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
channel catfish
Freshwater
Genes, MHC Class II - genetics
Ictaluridae - genetics
Ictalurus punctatus
major histocompatibility complex
MHC class II B genes
MHC class II β chains
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
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Summary:Two different cDNA sequences for major histocompatibility complex (MHC) class II β chains from the channel catfish ( Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus. The inferred amino acid sequences show strong evidence for a functional polypeptide chain with a peptide binding region. Southern blot analysis reveals polymorphism in the MHC class II B gene(s) of the channel catfish and suggests the presence of two to four genes.
ISSN:0145-305X
1879-0089
DOI:10.1016/S0145-305X(97)00003-7