Glycogen metabolism in the aerobic hypertrophied rat heart

Rates of glycolysis from exogenous glucose are accelerated in hypertrophied hearts. In this study, we determined whether alterations in the metabolism of glycogen, an endogenous storage form of glucose, also occur in hypertrophied hearts. Rates of glycolysis ([3H]H2O production) and oxidation ([14C]...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-07, Vol.96 (2), p.676-682
Main Authors: ALLARD, M. F, HENNING, S. L, WAMBOLT, R. B, GRANLEESE, S. R, ENGLISH, D. R, LOPASCHUK, G. D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Cardiomegaly - metabolism
Glucose - metabolism
Glycogen - metabolism
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Male
Medical sciences
Oxidation-Reduction
Rats
Rats, Sprague-Dawley
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Summary:Rates of glycolysis from exogenous glucose are accelerated in hypertrophied hearts. In this study, we determined whether alterations in the metabolism of glycogen, an endogenous storage form of glucose, also occur in hypertrophied hearts. Rates of glycolysis ([3H]H2O production) and oxidation ([14C]CO2 production) from exogenous glucose and glycogen were measured in isolated working hearts from control and aortic-banded rats. Hearts in which glycogen was prelabeled with [5-(3)H]- or [U-(14)C]glucose were perfused with buffer containing 11 mmol/L [5-(3)H]- or [U-(14)C]glucose (different from the isotope used to prelabel glycogen), 0.4 mmol/L palmitate, 0.5 mmol/L lactate, and 100 microU/mL insulin. Rates of glycolysis from exogenous glucose were greater (3471+/-114 versus 2665+/-194 nmol glucose x min(-1) x g dry wt(-1), P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.96.2.676