Concepts of Fever: Recent Advances and Lingering Dogma

Fever has been a preoccupation of clinicians since medicine's beginning. One might therefore expect that basic concepts relating to this physiological response would be well delineated and that such concepts would be widely known. In fact, only in the past several decades has the febrile respon...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 1997-07, Vol.25 (1), p.119-138
Main Authors: Mackowiak, Philip A., Borden, Ernest C., Goldblum, Simeon E., Hasday, Jeffrey D., Munford, Robert S., Nasraway, Stanley A., Stolley, Paul D., Woodward, Theodore E.
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - physiology
AIDS
AIDS/HIV
Biological and medical sciences
Body Temperature
Cytokines
Cytokines - antagonists & inhibitors
Cytokines - physiology
Fever
Fever - etiology
Fever - physiopathology
Fever - therapy
Forecasting
General aspects
HIV Infections - physiopathology
Human infectious diseases. Experimental studies and models
Humans
Infections
Infectious diseases
Medical sciences
Receptors
Review Articles
Sepsis
Systemic lupus erythematosus
Temperature measurement
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fever has been a preoccupation of clinicians since medicine's beginning. One might therefore expect that basic concepts relating to this physiological response would be well delineated and that such concepts would be widely known. In fact, only in the past several decades has the febrile response been subjected to scientific scrutiny. As a result of recent scientific investigation, modern concepts have evolved from a perception of fever as nothing more than a rise in core temperature to one in which fever is recognized as a complex physiological response characterized by a cytokinemediated rise in temperature, as well as by generation of acute-phase reactants and activation of a panoply of physiological, endocrinologic, and immunologic systems. The average clinician appears to have little more than a regrettably rudimentary knowledge of these modern concepts of fever. This symposium summary considers many such concepts that have immediate relevance to the practice of medicine.
ISSN:1058-4838
1537-6591
DOI:10.1086/514520