Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery

Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CA...

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Bibliographic Details
Published in:Atherosclerosis 1997-07, Vol.132 (2), p.215-219
Main Authors: Delanghe, Joris, Cambier, Bernard, Langlois, Michel, De Buyzere, Marc, Neels, Hugo, De Bacquer, Dirk, Van Cauwelaert, Philippe
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Adult
Aged
Alleles
Atherosclerosis
Biological and medical sciences
Coronary Artery Bypass
Coronary artery bypass grafting
Coronary Disease - genetics
Coronary Disease - surgery
Gene Frequency
Haptoglobin
Haptoglobins - genetics
Humans
Male
Medical sciences
Middle Aged
Polymorphism
Polymorphism, Genetic
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
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Summary:Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(97)00089-0