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Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery
Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CA...
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| Published in: | Atherosclerosis 1997-07, Vol.132 (2), p.215-219 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c389t-5c6f22a83d893b2721c1cf31a45a6637e590dece721a783bf1bcfe79534f916c3 |
| container_end_page | 219 |
| container_issue | 2 |
| container_start_page | 215 |
| container_title | Atherosclerosis |
| container_volume | 132 |
| creator | Delanghe, Joris Cambier, Bernard Langlois, Michel De Buyzere, Marc Neels, Hugo De Bacquer, Dirk Van Cauwelaert, Philippe |
| description | Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger ( |
| doi_str_mv | 10.1016/S0021-9150(97)00089-0 |
| format | article |
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P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.24–2.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction (
P<0.05), and among patients with a lower (<45 years) age at infarction (
P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type (
P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.]]></description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(97)00089-0</identifier><identifier>PMID: 9242967</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Acute myocardial infarction ; Adult ; Aged ; Alleles ; Atherosclerosis ; Biological and medical sciences ; Coronary Artery Bypass ; Coronary artery bypass grafting ; Coronary Disease - genetics ; Coronary Disease - surgery ; Gene Frequency ; Haptoglobin ; Haptoglobins - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymorphism ; Polymorphism, Genetic ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart</subject><ispartof>Atherosclerosis, 1997-07, Vol.132 (2), p.215-219</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-5c6f22a83d893b2721c1cf31a45a6637e590dece721a783bf1bcfe79534f916c3</citedby><cites>FETCH-LOGICAL-c389t-5c6f22a83d893b2721c1cf31a45a6637e590dece721a783bf1bcfe79534f916c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2747248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9242967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delanghe, Joris</creatorcontrib><creatorcontrib>Cambier, Bernard</creatorcontrib><creatorcontrib>Langlois, Michel</creatorcontrib><creatorcontrib>De Buyzere, Marc</creatorcontrib><creatorcontrib>Neels, Hugo</creatorcontrib><creatorcontrib>De Bacquer, Dirk</creatorcontrib><creatorcontrib>Van Cauwelaert, Philippe</creatorcontrib><title>Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description><![CDATA[Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (<45 years) age group (
P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.24–2.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction (
P<0.05), and among patients with a lower (<45 years) age at infarction (
P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type (
P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.]]></description><subject>Acute myocardial infarction</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Coronary Artery Bypass</subject><subject>Coronary artery bypass grafting</subject><subject>Coronary Disease - genetics</subject><subject>Coronary Disease - surgery</subject><subject>Gene Frequency</subject><subject>Haptoglobin</subject><subject>Haptoglobins - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkE1L7DAUhoMoOlf9CUIXIl6wmqQfSVYicq8Kgoi6DunpyRhtm5p0hPn3RmeYratDeJ_zkYeQI0bPGWX1xROlnOWKVfRUib-UUqlyukVmTAqVs1KW22S2QfbInxjfElQKJnfJruIlV7WYkcdbM05-3vnGDdnou2Xvw_jqYn-WmWyOA04OsuDie2YNTD5kCQMf_GDCMjNhwlSa5WhizOIizNPzgOxY00U8XNd98vL_3_P1bX7_cHN3fXWfQyHVlFdQW86NLFqpioYLzoCBLZgpK1PXhcBK0RYBU2CELBrLGrAoVFWUVrEain1yspo7Bv-xwDjp3kXArjMD-kXUQjGRvq8SWK1ACD7GgFaPwfXpfs2o_lapf1Tqb09aCf2jUtPUd7ResGh6bDdda3cpP17nJoLpbDADuLjBuCgFL2XCLlcYJhmfDoOO4HAAbF1AmHTr3S-HfAGDipCb</recordid><startdate>19970725</startdate><enddate>19970725</enddate><creator>Delanghe, Joris</creator><creator>Cambier, Bernard</creator><creator>Langlois, Michel</creator><creator>De Buyzere, Marc</creator><creator>Neels, Hugo</creator><creator>De Bacquer, Dirk</creator><creator>Van Cauwelaert, Philippe</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970725</creationdate><title>Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery</title><author>Delanghe, Joris ; Cambier, Bernard ; Langlois, Michel ; De Buyzere, Marc ; Neels, Hugo ; De Bacquer, Dirk ; Van Cauwelaert, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5c6f22a83d893b2721c1cf31a45a6637e590dece721a783bf1bcfe79534f916c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute myocardial infarction</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Coronary Artery Bypass</topic><topic>Coronary artery bypass grafting</topic><topic>Coronary Disease - genetics</topic><topic>Coronary Disease - surgery</topic><topic>Gene Frequency</topic><topic>Haptoglobin</topic><topic>Haptoglobins - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delanghe, Joris</creatorcontrib><creatorcontrib>Cambier, Bernard</creatorcontrib><creatorcontrib>Langlois, Michel</creatorcontrib><creatorcontrib>De Buyzere, Marc</creatorcontrib><creatorcontrib>Neels, Hugo</creatorcontrib><creatorcontrib>De Bacquer, Dirk</creatorcontrib><creatorcontrib>Van Cauwelaert, Philippe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delanghe, Joris</au><au>Cambier, Bernard</au><au>Langlois, Michel</au><au>De Buyzere, Marc</au><au>Neels, Hugo</au><au>De Bacquer, Dirk</au><au>Van Cauwelaert, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1997-07-25</date><risdate>1997</risdate><volume>132</volume><issue>2</issue><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract><![CDATA[Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (<45 years) age group (
P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.24–2.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction (
P<0.05), and among patients with a lower (<45 years) age at infarction (
P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type (
P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.]]></abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9242967</pmid><doi>10.1016/S0021-9150(97)00089-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Atherosclerosis, 1997-07, Vol.132 (2), p.215-219 |
| issn | 0021-9150 1879-1484 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Acute myocardial infarction Adult Aged Alleles Atherosclerosis Biological and medical sciences Coronary Artery Bypass Coronary artery bypass grafting Coronary Disease - genetics Coronary Disease - surgery Gene Frequency Haptoglobin Haptoglobins - genetics Humans Male Medical sciences Middle Aged Polymorphism Polymorphism, Genetic Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart |
| title | Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery |
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