Kimura's disease

A 40‐year‐old white Caucasian man presented with a 6‐month history of a 1.5 × 1.5 cm nodular lesion on his left arm. No history of trauma preceeded the lesion and the patient was in good general health. Dermatologic examination revealed a solitary, red, painless nodule located on the left arm (Fig....

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Bibliographic Details
Published in:International journal of dermatology 1997-06, Vol.36 (6), p.437-439
Main Authors: Lenk, Nurdan, Artüz, Ferda, Kulaçoǧlu, Sezer, Alli, Nuran
Format: Article
Language:English
Subjects:
Adult
Angiolymphoid Hyperplasia with Eosinophilia - drug therapy
Angiolymphoid Hyperplasia with Eosinophilia - pathology
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Arm
Biological and medical sciences
Biopsy
Dermatology
Eosinophils - pathology
Fibrosis
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Hair Follicle - pathology
Humans
Injections, Intralesional
Lymphocytes - pathology
Male
Medical sciences
Plasma Cells - pathology
Skin - pathology
Triamcinolone Acetonide - administration & dosage
Triamcinolone Acetonide - therapeutic use
Tropical medicine
Tumors of the skin and soft tissue. Premalignant lesions
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Description
Summary:A 40‐year‐old white Caucasian man presented with a 6‐month history of a 1.5 × 1.5 cm nodular lesion on his left arm. No history of trauma preceeded the lesion and the patient was in good general health. Dermatologic examination revealed a solitary, red, painless nodule located on the left arm (Fig. 1). Histopathologic examination of punch biopsy revealed lymphoid follicles, some of which had active germinal centers in the deep dermis and subcutaneous tissue. Mixed infiltration of lymphocytes, plasma cells and many eosinophils were present in the interfollicular region. Infiltration of the germinal centers by eosinophils, causing partial destruction, was observed (Fig. 2A). There was also proliferation of thin‐walled small vessels and fibrosis in some parts of the interfollicular areas (Fig. 2B). Although Kimura's disease (KD) and angiolymphoid hyperplasia with eosinophilia (ALHE) were considered in the differential diagnosis, it was diagnosed as KD based on these histologic features. Further laboratory examinations were performed. Serum IgE was normal and peripheral eosinophilia was absent. The lesion regressed after biopsy. Complete healing was achieved with intralesional corticosteroid (triamcinolone acetonide) treatment.
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4362.1997.tb01124.x