The Factor V Leiden Mutation (R506Q) is not a Major Risk Factor for Migrainous Cerebral Infarction

The etiology of migrainous cerebral infarction is unknown, but may involve prothrombotic coagulation abnormalities. Therefore, we studied resistance to activated protein C and the presence of the Arg506Gln factor V Leiden mutation in 20 patients, with migrainous cerebral infarction. Only one heteroz...

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Bibliographic Details
Published in:Cephalalgia 1997-08, Vol.17 (5), p.605-607
Main Authors: Haan, J, Kappelle, LJ, de Ronde, H, Ferrari, MD, Bertina, RM
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cerebral Infarction - etiology
Factor V - genetics
Factor V mutation
Female
Humans
Male
Middle Aged
migraine
Migraine Disorders - complications
Migraine Disorders - genetics
migrainous cerebral infarction resistance to activated protein C
Mutation - genetics
Protein C
Risk Factors
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Summary:The etiology of migrainous cerebral infarction is unknown, but may involve prothrombotic coagulation abnormalities. Therefore, we studied resistance to activated protein C and the presence of the Arg506Gln factor V Leiden mutation in 20 patients, with migrainous cerebral infarction. Only one heterozygous carrier of the mutation was found, whereas other patients did not carry the mutation. This indicates that the factor V Leiden mutation is not a major risk factor for migrainous cerebral infarction.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1997.1705605.x