Papillary adenocarcinoma of the sigmoid colon associated with psammoma bodies and hyaline globules: report of a case

We report a case of papillary adenocarcinoma of the sigmoid colon with psammoma bodies and intracytoplasmic hyaline globules. The patient was a 59-year-old woman. The tumor showed central ulceration with smooth elevated ridges. Histologically, the tumor was composed of numerous large irregular tubul...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 1997-06, Vol.27 (3), p.193-196
Main Authors: Nakayama, H, Okumichi, T, Nakashima, S, Kimura, A, Ikeda, M, Kajihara, H
Format: Article
Language:English
Subjects:
Adenocarcinoma, Papillary - pathology
Calcinosis - pathology
Female
Humans
Hyalin - ultrastructure
Inclusion Bodies - ultrastructure
Middle Aged
Sigmoid Neoplasms - pathology
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Summary:We report a case of papillary adenocarcinoma of the sigmoid colon with psammoma bodies and intracytoplasmic hyaline globules. The patient was a 59-year-old woman. The tumor showed central ulceration with smooth elevated ridges. Histologically, the tumor was composed of numerous large irregular tubular structures accompanying infolded papillary growth. The tumor cells showed cytoplasmic basophilia and prominent nuclear atypia. Psammomatous-type calcification was scattered in the tumor stroma as well as in the glandular lumina. In addition, intracytoplasmic hyaline globules of various sizes were seen in the neoplastic cells. We propose the name papillary adenocarcinoma associated with psammoma bodies and hyaline globules for this tumor. Accumulation of further cases is needed to clarify the clinical significance of this type of tumor.
ISSN:0368-2811
1465-3621
1465-3621
DOI:10.1093/jjco/27.3.193