Michellamines D−F, New HIV-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, and Korupensamine E, a New Antimalarial Monomer, from Ancistrocladus korupensis

New monomeric (korupensamine E, 6) and dimeric (michellamines D−F, 7−9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, c...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-07, Vol.60 (7), p.677-683
Main Authors: Hallock, Yali F, Manfredi, Kirk P, Dai, Jin-Rui, Cardellina, John H, Gulakowski, Robert J, McMahon, James B, Schäffer, Manuela, Stahl, Martin, Gulden, Klaus-Peter, Bringmann, Gerhard, François, Guido, Boyd, Michael R
Format: Article
Language:English
Subjects:
AIDS/HIV
Anti-HIV Agents - chemistry
Anti-HIV Agents - isolation & purification
Anti-HIV Agents - pharmacology
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Biological and medical sciences
General pharmacology
Isoquinolines - chemistry
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
Medical sciences
Naphthalenes - chemistry
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Spectrum Analysis
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Summary:New monomeric (korupensamine E, 6) and dimeric (michellamines D−F, 7−9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A−D.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9700679