Autosomal dominant polycystic kidney disease in a kidney transplant population

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 1997-07, Vol.12 (7), p.1431-1436
• Main Authors: HADIMERI, H, NORDEN, G, FRIMAN, S, NYBERG, G
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; Female; Humans; Kidney Transplantation; Male; Medical sciences; Middle Aged; Polycystic Kidney, Autosomal Dominant - complications; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/12.7.1431

To define specific manifestations of autosomal dominant polycystic kidney disease in kidney transplant patients. Of 874 consecutive first renal transplant patients 1985-1993, 114 (13%) had autosomal dominant polycystic kidney disease (ADPKD). Mean age was 53 +/- 8 years, 62% were men, and 83% received cadaveric kidneys. Control patients were matched for sex, age and donor type. Median follow-up time was 63 months. One patient was lost to follow-up. Medical records before and after transplantation were reviewed. Survival of patients and grafts was similar in ADPKD patients and controls. Twenty-five ADPKD patients died, four of causes not seen in the controls; two aortic aneurysms, one urothelial cancer, one colon perforation. Four more ADPKD patients but no control had diverticulitis (P = 0.03), two with perforation. Cardiovascular morbidity was not increased. Eight patients had subarachnoidal haemorrhage before transplantation and two during follow-up. Nineteen patients had undergone nephrectomy before transplantation, 11 because of voluminous kidneys, five for infection, pain or bleeding, two for suspected malignancy, one for hypertension. After transplantation, seven patients underwent nephrectomy, only one related to kidney size. During the first year, need of phlebotomy occurred in 14% of patients versus 4% of controls, P = 0.02. Urinary tract infection rates were not increased. No morbidity was related to liver cysts. The specific features of kidney transplantation to patients with ADPKD were few: enlarged kidneys, relevant only before transplantation, erythrocytosis, and as rare but serious events, diverticulitis with perforation.