Loading…
Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome
Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syn...
Saved in:
Published in: | The journal of clinical endocrinology and metabolism 1997-08, Vol.82 (8), p.2542-2547 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c381t-b0935de21a939c09caebe3206c3e6f08c2e3c1204813d29434a7ac82a4eef7173 |
---|---|
cites | |
container_end_page | 2547 |
container_issue | 8 |
container_start_page | 2542 |
container_title | The journal of clinical endocrinology and metabolism |
container_volume | 82 |
creator | MASUZAKI, H OGAWA, Y NAKAO, K HOSODA, K MIYAWAKI, T HANAOKA, I HIRAOKA, J YASUNO, A NISHIMURA, H YOSHIMASA, Y NISHI, S |
description | Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome were significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the administration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans. |
doi_str_mv | 10.1210/jc.82.8.2542 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79186544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79186544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-b0935de21a939c09caebe3206c3e6f08c2e3c1204813d29434a7ac82a4eef7173</originalsourceid><addsrcrecordid>eNo90M1LHDEYBvBQKnarvXkVcij10lnzNZPEW1msFQQvLfQWspl33CyZyTbvjCD-887W1VMgz-99Dg8hZ5wtueDschuWRizNUtRKfCALblVdaW71R7JgTPDKavH3E_mMuGWMK1XLY3JsRS2l5AvyfJOmkEMuYww5trTAw5T8GPNAc0cT7MY4UHwaxg1gROqHliKEAv_FHG2m3g9Ir-h1gkc_Qkt3yWPv307nX0i4l6sJN3F4uMB9XVtyD6fkqPMJ4cvhPSF_fl7_Xv2q7u5vblc_7qogDR-rNbOybkFwb6UNzAYPa5CCNUFC0zETBMjABVOGy1ZYJZXXPhjhFUCnuZYn5Ntr767kfxPg6PqIAVLyA-QJnbbcNLVSM_z-CkPJiAU6tyux9-XJceb2W7ttcEY44_Zbz_z80Dute2jf8WHcOf96yD0Gn7rihxDxnQmtWdM08gWrN4jE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79186544</pqid></control><display><type>article</type><title>Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome</title><source>Oxford Journals Online</source><creator>MASUZAKI, H ; OGAWA, Y ; NAKAO, K ; HOSODA, K ; MIYAWAKI, T ; HANAOKA, I ; HIRAOKA, J ; YASUNO, A ; NISHIMURA, H ; YOSHIMASA, Y ; NISHI, S</creator><creatorcontrib>MASUZAKI, H ; OGAWA, Y ; NAKAO, K ; HOSODA, K ; MIYAWAKI, T ; HANAOKA, I ; HIRAOKA, J ; YASUNO, A ; NISHIMURA, H ; YOSHIMASA, Y ; NISHI, S</creatorcontrib><description>Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome were significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the administration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.82.8.2542</identifier><identifier>PMID: 9253331</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adenoma - blood ; Adenoma - surgery ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Adolescent ; Adrenal Gland Neoplasms - blood ; Adrenal Gland Neoplasms - surgery ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Biological and medical sciences ; Cushing Syndrome - blood ; Dexamethasone - pharmacology ; Endocrinopathies ; Female ; Gene Expression ; Glucocorticoids - pharmacology ; Humans ; Hydrocortisone - blood ; Leptin ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Organ Culture Techniques ; Pituitary Neoplasms - blood ; Pituitary Neoplasms - surgery ; Protein Biosynthesis ; Proteins - genetics ; Proteins - metabolism</subject><ispartof>The journal of clinical endocrinology and metabolism, 1997-08, Vol.82 (8), p.2542-2547</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-b0935de21a939c09caebe3206c3e6f08c2e3c1204813d29434a7ac82a4eef7173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2770666$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9253331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MASUZAKI, H</creatorcontrib><creatorcontrib>OGAWA, Y</creatorcontrib><creatorcontrib>NAKAO, K</creatorcontrib><creatorcontrib>HOSODA, K</creatorcontrib><creatorcontrib>MIYAWAKI, T</creatorcontrib><creatorcontrib>HANAOKA, I</creatorcontrib><creatorcontrib>HIRAOKA, J</creatorcontrib><creatorcontrib>YASUNO, A</creatorcontrib><creatorcontrib>NISHIMURA, H</creatorcontrib><creatorcontrib>YOSHIMASA, Y</creatorcontrib><creatorcontrib>NISHI, S</creatorcontrib><title>Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome were significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the administration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.</description><subject>Adenoma - blood</subject><subject>Adenoma - surgery</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Adolescent</subject><subject>Adrenal Gland Neoplasms - blood</subject><subject>Adrenal Gland Neoplasms - surgery</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cushing Syndrome - blood</subject><subject>Dexamethasone - pharmacology</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Glucocorticoids - pharmacology</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Organ Culture Techniques</subject><subject>Pituitary Neoplasms - blood</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Protein Biosynthesis</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNo90M1LHDEYBvBQKnarvXkVcij10lnzNZPEW1msFQQvLfQWspl33CyZyTbvjCD-887W1VMgz-99Dg8hZ5wtueDschuWRizNUtRKfCALblVdaW71R7JgTPDKavH3E_mMuGWMK1XLY3JsRS2l5AvyfJOmkEMuYww5trTAw5T8GPNAc0cT7MY4UHwaxg1gROqHliKEAv_FHG2m3g9Ir-h1gkc_Qkt3yWPv307nX0i4l6sJN3F4uMB9XVtyD6fkqPMJ4cvhPSF_fl7_Xv2q7u5vblc_7qogDR-rNbOybkFwb6UNzAYPa5CCNUFC0zETBMjABVOGy1ZYJZXXPhjhFUCnuZYn5Ntr767kfxPg6PqIAVLyA-QJnbbcNLVSM_z-CkPJiAU6tyux9-XJceb2W7ttcEY44_Zbz_z80Dute2jf8WHcOf96yD0Gn7rihxDxnQmtWdM08gWrN4jE</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>MASUZAKI, H</creator><creator>OGAWA, Y</creator><creator>NAKAO, K</creator><creator>HOSODA, K</creator><creator>MIYAWAKI, T</creator><creator>HANAOKA, I</creator><creator>HIRAOKA, J</creator><creator>YASUNO, A</creator><creator>NISHIMURA, H</creator><creator>YOSHIMASA, Y</creator><creator>NISHI, S</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome</title><author>MASUZAKI, H ; OGAWA, Y ; NAKAO, K ; HOSODA, K ; MIYAWAKI, T ; HANAOKA, I ; HIRAOKA, J ; YASUNO, A ; NISHIMURA, H ; YOSHIMASA, Y ; NISHI, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-b0935de21a939c09caebe3206c3e6f08c2e3c1204813d29434a7ac82a4eef7173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenoma - blood</topic><topic>Adenoma - surgery</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Adolescent</topic><topic>Adrenal Gland Neoplasms - blood</topic><topic>Adrenal Gland Neoplasms - surgery</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cushing Syndrome - blood</topic><topic>Dexamethasone - pharmacology</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Glucocorticoids - pharmacology</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Organ Culture Techniques</topic><topic>Pituitary Neoplasms - blood</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Protein Biosynthesis</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MASUZAKI, H</creatorcontrib><creatorcontrib>OGAWA, Y</creatorcontrib><creatorcontrib>NAKAO, K</creatorcontrib><creatorcontrib>HOSODA, K</creatorcontrib><creatorcontrib>MIYAWAKI, T</creatorcontrib><creatorcontrib>HANAOKA, I</creatorcontrib><creatorcontrib>HIRAOKA, J</creatorcontrib><creatorcontrib>YASUNO, A</creatorcontrib><creatorcontrib>NISHIMURA, H</creatorcontrib><creatorcontrib>YOSHIMASA, Y</creatorcontrib><creatorcontrib>NISHI, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MASUZAKI, H</au><au>OGAWA, Y</au><au>NAKAO, K</au><au>HOSODA, K</au><au>MIYAWAKI, T</au><au>HANAOKA, I</au><au>HIRAOKA, J</au><au>YASUNO, A</au><au>NISHIMURA, H</au><au>YOSHIMASA, Y</au><au>NISHI, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>82</volume><issue>8</issue><spage>2542</spage><epage>2547</epage><pages>2542-2547</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome were significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the administration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>9253331</pmid><doi>10.1210/jc.82.8.2542</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0021-972X |
ispartof | The journal of clinical endocrinology and metabolism, 1997-08, Vol.82 (8), p.2542-2547 |
issn | 0021-972X 1945-7197 |
language | eng |
recordid | cdi_proquest_miscellaneous_79186544 |
source | Oxford Journals Online |
subjects | Adenoma - blood Adenoma - surgery Adipose Tissue - drug effects Adipose Tissue - metabolism Adolescent Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - surgery Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Biological and medical sciences Cushing Syndrome - blood Dexamethasone - pharmacology Endocrinopathies Female Gene Expression Glucocorticoids - pharmacology Humans Hydrocortisone - blood Leptin Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Organ Culture Techniques Pituitary Neoplasms - blood Pituitary Neoplasms - surgery Protein Biosynthesis Proteins - genetics Proteins - metabolism |
title | Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A38%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glucocorticoid%20regulation%20of%20leptin%20synthesis%20and%20secretion%20in%20humans%20:%20Elevated%20plasma%20leptin%20levels%20in%20Cushing's%20syndrome&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=MASUZAKI,%20H&rft.date=1997-08-01&rft.volume=82&rft.issue=8&rft.spage=2542&rft.epage=2547&rft.pages=2542-2547&rft.issn=0021-972X&rft.eissn=1945-7197&rft.coden=JCEMAZ&rft_id=info:doi/10.1210/jc.82.8.2542&rft_dat=%3Cproquest_cross%3E79186544%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c381t-b0935de21a939c09caebe3206c3e6f08c2e3c1204813d29434a7ac82a4eef7173%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79186544&rft_id=info:pmid/9253331&rfr_iscdi=true |