Protection of piperacillin and ticarcillin from β-lactamase hydrolysis by tazobactam (YTR-830) and clavulanic acid

Tazobactam (YTR-830) is a penicillanic acid sulphone which has been shown to be an active beta -lactamase inhibitor. The beta -lactam antibiotic that is likely to be used in combination with tazobactam is piperacillin. It is therefore important to assess the protection afforded to piperacillin by ta...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1989-07, Vol.24 (1), p.89-92
Main Authors: DIVER, J. M., THORNBER, D., WISE, R.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamase Inhibitors
beta-Lactamases - metabolism
Biological and medical sciences
Clavulanic Acids - pharmacology
Escherichia coli - enzymology
Hydrolysis
Medical sciences
Penicillanic Acid - pharmacology
Penicillins - metabolism
Pharmacology. Drug treatments
Piperacillin - metabolism
Staphylococcus aureus - enzymology
Tazobactam
Ticarcillin - metabolism
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Description
Summary:Tazobactam (YTR-830) is a penicillanic acid sulphone which has been shown to be an active beta -lactamase inhibitor. The beta -lactam antibiotic that is likely to be used in combination with tazobactam is piperacillin. It is therefore important to assess the protection afforded to piperacillin by tazobactam. The aim of this study was to investigate the inhibitory properties of tazobactam against beta -lactamases from Staphylococcus aureus (penicillinase enzyme) and Escherichia coli (TEM-1 enzyme).
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/24.1.89