Genetic control of interleukin 12 responsiveness : implications for disease pathogenesis

We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysi...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 1997-07, Vol.75 (7), p.502-511
Main Authors: GORHAM, J. D, GÜLER, M. L, MURPHY, K. M
Format: Article
Language:English
Subjects:
Animals
Atopy
Biological and medical sciences
Disease Models, Animal
Disease Susceptibility - immunology
Experimental and animal immunopathology. Animal models
Gene Expression Regulation - immunology
Genetic Predisposition to Disease
Humans
Immunopathology
Interleukin-12 - genetics
Medical sciences
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Summary:We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.
ISSN:0946-2716
1432-1440
DOI:10.1007/s001090050135